Bi-Est 50:50
Personalized
Hormone Therapy
Clinician-guided bioidentical blend of estradiol, estriol, and progesterone for menopause relief and hormonal balance.
Available as Bi-Est 50:50 cream — with or without Progesterone. Your clinician may also prescribe a vaginal cream if needed.
Balances Hormones Naturally
Estradiol and estriol ease hot flashes and mood swings.
Promotes Restful Sleep
Progesterone supports calm, deeper rest, and emotional balance.
Improves Skin Elasticity & Tone
Encourages collagen renewal and healthy radiance.
💎 Intro Offer: $84/mo (15% Off) first 6 months | then $99/mo.*
Included: Clinician Review · Rx Medication · Free Shipping
| HSA & FSA Eligible | Free 2-Day shipping
As estrogen and progesterone decline, menopause symptoms like hot flashes, poor sleep, and mood shifts can appear. Bi-Est 50:50 helps restore balance for calm, energy, and well-being.
NEW
*Pricing reflects billing on a 3-month plan. Prescriptions provided only when clinically appropriate and approved by a licensed provider. Compounded by U.S. 503A pharmacies. Not FDA-evaluated; not intended to diagnose, treat, cure, or prevent disease. Orders placed on weekends ship the next business day.
Claim Your 15% Off - Find Your Ideal Hormone Plan
The Hidden Curve Behind Energy, Mood, and Calm
Estrogen and progesterone naturally fluctuate throughout a woman’s life — peaking in the 20s and 30s, then steadily declining as menopause approaches.
When progesterone begins to drop in the 40s, sleep and stress balance can shift. As estrogen levels follow, symptoms such as hot flashes, mood swings, and fatigue often appear.
Bi-Est 50:50 combines estradiol (E2) and estriol (E3) — with or without progesterone — to help restore hormonal balance, supporting calm, energy, and emotional stability through clinician-guided bioidentical therapy.
Discover how BeMediq’s personalized Bi-Est 50:50 therapy can help you feel balanced, clear, and in control again.
When progesterone begins to drop in the 40s, sleep and stress balance can shift. As estrogen levels follow, symptoms such as hot flashes, mood swings, and fatigue often appear.
Bi-Est 50:50 combines estradiol (E2) and estriol (E3) — with or without progesterone — to help restore hormonal balance, supporting calm, energy, and emotional stability through clinician-guided bioidentical therapy.
Discover how BeMediq’s personalized Bi-Est 50:50 therapy can help you feel balanced, clear, and in control again.
Your Body’s Signals of Hormonal Change
These are the symptoms Bi-Est 50:50 is designed to ease through gentle, bioidentical hormone balance.
Hot flashes
Mood swings
Insomnia
Thinning hair
Bloating
Brain fog
Anger
Headaches
Fatigue
Anxiety
Depression
Weight gain
RESTFUL SLEEP
Balanced progesterone can make it easier to unwind and stay asleep.
Learn More
HOT FLASH RELIEVE
Declining estrogen can trigger sudden warmth — Bi-Est 50:50 helps restore balance
Learn More
EMOTIONAL BALANCE
Hormonal changes impact mood and calm; Bi-Est 50:50 supports emotional steadiness.
Learn More
HORMONAL HARMONY
When estrogen and progesterone fall out of sync, Bi-Est 50:50 helps realign them naturally.
Learn More
RESTFUL SLEEP
Restore Your Deep, Restful Sleep - Naturally
Wake up feeling refreshed and energized.
As women enter their 40s and 50s, levels of estrogen and progesterone decline, disrupting the body’s natural sleep rhythms.
- Progesterone has a gentle, calming effect on the brain — helping quiet the nervous system and support relaxation before sleep.
- Estrogen influences serotonin and body temperature, both of which affect how easily you fall and stay asleep.
When these hormones drop, restlessness, frequent waking, and lighter sleep often follow. Many women describe feeling tired but wired — unable to fully unwind even when exhausted.
Based on your symptoms, your clinician may recommend:
- Bi-Est 50:50 (Estradiol + Estriol) – to support more restful, uninterrupted sleep by balancing estrogen levels that influence temperature and serotonin.
- Bi-Est 50:50 with Progesterone – when combined hormone support is clinically appropriate to promote calm, relaxation, and deeper restorative rest.
All medications are compounded by licensed U.S. 503A pharmacies using FDA-registered ingredients and dispensed under licensed provider supervision.
- Progesterone has a gentle, calming effect on the brain — helping quiet the nervous system and support relaxation before sleep.
- Estrogen influences serotonin and body temperature, both of which affect how easily you fall and stay asleep.
When these hormones drop, restlessness, frequent waking, and lighter sleep often follow. Many women describe feeling tired but wired — unable to fully unwind even when exhausted.
Based on your symptoms, your clinician may recommend:
- Bi-Est 50:50 (Estradiol + Estriol) – to support more restful, uninterrupted sleep by balancing estrogen levels that influence temperature and serotonin.
- Bi-Est 50:50 with Progesterone – when combined hormone support is clinically appropriate to promote calm, relaxation, and deeper restorative rest.
All medications are compounded by licensed U.S. 503A pharmacies using FDA-registered ingredients and dispensed under licensed provider supervision.
Compounded medications are prepared individually for each prescription and are not reviewed by the FDA. Prescriptions are provided only if clinically appropriate after review by a licensed provider.
HOT FLASH RELIEF
Cool, Calm, and Comfortable - Day and Night.
Helping you stay cool, balanced, and at ease.
As estrogen levels decline during perimenopause and menopause, your body’s internal thermostat becomes more sensitive. Even small hormonal shifts can trigger sudden warmth, flushing, or night sweats that interrupt rest and daily comfort.
Estrogen helps regulate temperature, blood flow, and serotonin — all key to feeling balanced and at ease. When levels drop, these systems become less stable, leading to the familiar waves of heat and sweating.
Based on your symptoms, your clinician may recommend:
- Bi-Est 50:50 (Estradiol + Estriol) – tto support estrogen balance and temperature regulation.
- Bi-Est 50:50 with Progesterone – when combined hormone support is clinically appropriate for managing hot flashes, night sweats, and sleep disruption.
All medications are compounded by licensed U.S. 503A pharmacies using FDA-registered ingredients and dispensed under provider supervision.
Estrogen helps regulate temperature, blood flow, and serotonin — all key to feeling balanced and at ease. When levels drop, these systems become less stable, leading to the familiar waves of heat and sweating.
Based on your symptoms, your clinician may recommend:
- Bi-Est 50:50 (Estradiol + Estriol) – tto support estrogen balance and temperature regulation.
- Bi-Est 50:50 with Progesterone – when combined hormone support is clinically appropriate for managing hot flashes, night sweats, and sleep disruption.
All medications are compounded by licensed U.S. 503A pharmacies using FDA-registered ingredients and dispensed under provider supervision.
Compounded medications are prepared individually for each prescription and are not reviewed by the FDA. Prescriptions are provided only if clinically appropriate after review by a licensed provider.
EMOTIONAL BALANCE
Feel Steady, Calm, and Centered Every Day.
Restore Emotional Balance & Wellbeing.
As estrogen and progesterone levels decline, many women experience shifts in mood, focus, and emotional resilience. These hormones influence key neurotransmitters such as serotonin and GABA, which help regulate calm, stability, and the body’s stress response.
When hormone levels fluctuate, irritability, anxiety, or mood swings may appear — often without clear triggers. Understanding this connection helps explain why maintaining emotional balance can feel more difficult during midlife.
Based on your symptoms, your clinician may recommend:
- Bi-Est 50:50 (Estradiol + Estriol) – formulated to support mood, calm, and mental clarity by helping regulate serotonin and GABA pathways affected by estrogen decline.
- Bi-Est 50:50 with Progesterone – when combined support is clinically appropriate to enhance relaxation, emotional stability, and overall sense of well-being.
All medications are compounded by licensed U.S. 503A pharmacies using FDA-registered ingredients and dispensed under licensed provider supervision.
When hormone levels fluctuate, irritability, anxiety, or mood swings may appear — often without clear triggers. Understanding this connection helps explain why maintaining emotional balance can feel more difficult during midlife.
Based on your symptoms, your clinician may recommend:
- Bi-Est 50:50 (Estradiol + Estriol) – formulated to support mood, calm, and mental clarity by helping regulate serotonin and GABA pathways affected by estrogen decline.
- Bi-Est 50:50 with Progesterone – when combined support is clinically appropriate to enhance relaxation, emotional stability, and overall sense of well-being.
All medications are compounded by licensed U.S. 503A pharmacies using FDA-registered ingredients and dispensed under licensed provider supervision.
Compounded medications are prepared individually for each prescription and are not reviewed by the FDA. Prescriptions are provided only if clinically appropriate after review by a licensed provider.
HORMONAL HARMONY
Rebalance Your Body’s Natural Rhythm.
Feel renewed energy, focus, and balance as your hormones realign.
Estrogen and progesterone work together to regulate energy, metabolism, and mental clarity. As these hormones decline, it’s common to feel more fatigued, less focused, and off balance.
Hormonal shifts can affect everything from blood sugar stability to mood and motivation — subtle changes that gradually influence how you feel each day. Restoring your body’s natural rhythm helps bring back steady energy and a sense of well-being.
Based on your symptoms, your clinician may recommend:
- Bi-Est 50:50 (Estradiol + Estriol) – to restore estrogen balance, supporting focus, energy, and overall well-being.
- Bi-Est 50:50 with Progesterone – when combined hormone support is clinically appropriate for maintaining mood and energy stability.
All medications are compounded by licensed U.S. 503A pharmacies using FDA-registered ingredients and dispensed under provider supervision.
Hormonal shifts can affect everything from blood sugar stability to mood and motivation — subtle changes that gradually influence how you feel each day. Restoring your body’s natural rhythm helps bring back steady energy and a sense of well-being.
Based on your symptoms, your clinician may recommend:
- Bi-Est 50:50 (Estradiol + Estriol) – to restore estrogen balance, supporting focus, energy, and overall well-being.
- Bi-Est 50:50 with Progesterone – when combined hormone support is clinically appropriate for maintaining mood and energy stability.
All medications are compounded by licensed U.S. 503A pharmacies using FDA-registered ingredients and dispensed under provider supervision.
Compounded medications are prepared individually for each prescription and are not reviewed by the FDA. Prescriptions are provided only if clinically appropriate after review by a licensed provider.
Recharge Your Body with Glutathione
What’s Included in Your Bi-Est 50:50 Program
Everything you need, delivered to your door.
When prescribed, your Bi-Est 50:50 program includes a complete treatment plan — designed for safe, clinician-guided hormone therapy at home:
· Bi-Est 50:50 cream (compounded in 505A licensed U.S. pharmacies)
· Step-by-Step usage instructions from your licensed provider
· Ongoing prescription refills shipped to your home (cancel anytime)
· Access to your provider for follow-up care
Formulation: Bi-Est 50:50 (Estradiol + Estriol), available with or without Progesterone.
Available only with a valid prescription after review by a licensed U.S. provider. Supplies and instructions are customized to your individual treatment plan.
· Bi-Est 50:50 cream (compounded in 505A licensed U.S. pharmacies)
· Step-by-Step usage instructions from your licensed provider
· Ongoing prescription refills shipped to your home (cancel anytime)
· Access to your provider for follow-up care
Formulation: Bi-Est 50:50 (Estradiol + Estriol), available with or without Progesterone.
Available only with a valid prescription after review by a licensed U.S. provider. Supplies and instructions are customized to your individual treatment plan.
Bi-Est 50:50 helps restore hormonal balance to support calm, energy, sleep, and overall well-being.
Get Your Treatment in 3 Easy Steps
BeMediq is a modern telehealth platform that connects you with licensed medical providers who personalize care for women’s health.
From your first online visit to treatment at your door, everything is designed to fit your life, not disrupt it.
From your first online visit to treatment at your door, everything is designed to fit your life, not disrupt it.
1
START ONLINE
Take 3-minute questionnaire
A licensed provider will review your
answers and personalize your care.
No appointments, No waiting rooms.
2
GET IT FAST
Free & Discreet Delivery
If approved, your medication is shipped directly to
your door in discreet packaging with free 2-Day shipping.
3
ONGOING CARE
Whenever You Need It
Have questions?
Our clinical team is here for you with
unlimited messaging and check-ins throughout your care journey.
FEEL THE DIFFERENCE
Most women report improved energy, mood, and hormonal balance - often within just a few weeks.*
*Individual results may vary. Treatment plans are personalized and based on provider evaluation.
Bioidentical Treatments Pricing & Plans
Bi-Est 50:50 Cream
(w. Progesterone)
(w. Progesterone)
$127/mo*
*(15% off) first month | then $149/mo
billed monthly
billed monthly
Bi-Est 50:50 Cream
(w. Progesterone)
(w. Progesterone)
$84/mo*
*(15% off) first 3 months | then $99/mo
billed quarterly
billed quarterly
Includes licensed provider review · U.S.-licensed pharmacy compounding · Free 2-Day shipping
Cruelty Free
Science Based
ECO Friendly
Silicon Free
Paraben Free
FDA-Approved Components
Bioidentical Hormone Balance: Frequently Asked Questions
Everything you need to know before getting started.
What is Bi-Est 50:50?
How does Bi-Est 50:50 help with menopause symptoms?
What’s the difference between Bi-Est 50:50 and other hormone therapies?
Why is progesterone sometimes added to Bi-Est 50:50?
How is Bi-Est 50:50 used?
How long does it take to feel results?
Is Bi-Est 50:50 safe?
Can Bi-Est 50:50 help with skin and hair changes?
How is Bi-Est 50:50 compounded?
Are there any side effects with Bi-Est 50:50?
Safety & Monitoring - Your wellbeing is our priority.
All bioidentical hormone prescriptions are reviewed by licensed U.S. providers and compounded in state-licensed 503A pharmacies using FDA-registered ingredients. Treatment plans are personalized, and dosing adjustments are made gradually to support safety, comfort, and optimal balance.
If you experience any new or concerning symptoms, pause treatment and contact your prescribing provider or pharmacist for guidance before resuming use..
If you experience any new or concerning symptoms, pause treatment and contact your prescribing provider or pharmacist for guidance before resuming use..
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From the BeMediq Journal
BeMediq™ is a digital health platform that connects patients with licensed, independent medical providers through a secure online interface. Medical services are provided exclusively by third-party physician groups, including Beluga Health, P.A., and affiliated networks. BeMediq™ does not itself provide medical or pharmacy services.
All diagnoses, treatment decisions, and prescriptions are made solely by licensed healthcare professionals after reviewing each patient’s health information. Payment does not guarantee a prescription, medication, or specific outcome.
Medication images and product visuals shown on this website are for illustrative purposes only. Actual formulations, packaging, and labeling may vary. Some medications available through BeMediq™ may be custom-compounded by licensed 503A U.S. pharmacies. These compounded formulations are prepared for individual prescriptions, have not been reviewed or approved by the U.S. Food and Drug Administration (FDA), and may differ from FDA-approved products. However, ingredients are typically sourced from FDA-registered suppliers, and pharmacies operate in compliance with state and federal compounding regulations.
Statements about potential benefits have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary. Medications should only be used as directed and under the supervision of a licensed provider.
BeMediq™ is not affiliated with, endorsed by, or sponsored by the manufacturers of FDA-approved brand-name drugs such as Ozempic®, Wegovy®, Mounjaro®, or Zepbound®. These trademarks are the property of their respective owners.BeMediq™ services are intended for adults 18+ and are not for use in emergencies. If you are experiencing a medical emergency, call 911 or seek immediate in-person care. Availability of services may vary by state and is subject to provider licensure and applicable regulations.
All health data is handled securely in accordance with HIPAA and applicable privacy laws. Please review our Terms of Service and Privacy Policy for more information.
All diagnoses, treatment decisions, and prescriptions are made solely by licensed healthcare professionals after reviewing each patient’s health information. Payment does not guarantee a prescription, medication, or specific outcome.
Medication images and product visuals shown on this website are for illustrative purposes only. Actual formulations, packaging, and labeling may vary. Some medications available through BeMediq™ may be custom-compounded by licensed 503A U.S. pharmacies. These compounded formulations are prepared for individual prescriptions, have not been reviewed or approved by the U.S. Food and Drug Administration (FDA), and may differ from FDA-approved products. However, ingredients are typically sourced from FDA-registered suppliers, and pharmacies operate in compliance with state and federal compounding regulations.
Statements about potential benefits have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary. Medications should only be used as directed and under the supervision of a licensed provider.
BeMediq™ is not affiliated with, endorsed by, or sponsored by the manufacturers of FDA-approved brand-name drugs such as Ozempic®, Wegovy®, Mounjaro®, or Zepbound®. These trademarks are the property of their respective owners.BeMediq™ services are intended for adults 18+ and are not for use in emergencies. If you are experiencing a medical emergency, call 911 or seek immediate in-person care. Availability of services may vary by state and is subject to provider licensure and applicable regulations.
All health data is handled securely in accordance with HIPAA and applicable privacy laws. Please review our Terms of Service and Privacy Policy for more information.
BeMediq works exclusively with HIPAA-compliant provider networks.
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